Posaconazole is a triazole antifungal drug, marketed by Schering-Plough. It is a derivative of Itraconazole.
Generic Name: posaconazole
Brand Name: Noxafil, Posanol
Indications, Side Effects, Warnings Consumer Information of posaconazole please refer to: www.drugs.com
Chemical information of posaconazole:
CAS#: 171228-49-2
Chemical name:4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
Chemical structure:

1. SANDOZ PRIVATE LTD (2010)
2. MSN LABORATORIES PRIVATE LTD (2013)
3. WUHAN ZY PHARMACEUTICAL CO LTD (2014)
4. BRIGHTGENE BIOMEDICAL TECHNOLOGY CO LTD (2014)
5. MSN LABORATORIES PRIVATE LTD (2015)
6. ZHEJIANG AUSUN PHARMACEUTICAL CO LTD(2016)
7. APOTEX PHARMACHEM INC (2016)
8. STRIDES SHASUN LTD (2017)
List of manufacturers of posaconazole in China (data from www.sfda.gov.cn):
1. Nanjing Zhengke
2. Jiangsu Hengsheng
3. Jiangsu Aosaikang
4. Chongqing Huabang Shengkai
5. Xinxiang Shuanglu
6. Henan Tailong
7. Shanghai Xiandai
8. Hebei Guolong
9. Jichuan Pharma
10. Wuhan Zhongyou
11. Shanxi Zhendong
12. Jiangsu Shengdi
13. Jiangsu Haici Bio-pharm
14. Chengdu Beite
15. Shanxi Pude
Advanced posaconazole intermediates:
1. CAS# 175712-02-4 :(5R-cis)- p-Chlorobenzenesulfonic acid 5-(2,4-difluoro-
phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethyl ester
Chemical structure:
1. CAS# 175712-02-4 :(5R-cis)- p-Chlorobenzenesulfonic acid 5-(2,4-difluoro-
phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethyl ester
Chemical structure:
2. CAS# 184177-83-1 : 2-[(1S,2S)-1-ethyl-2-bezyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- 3H-1,2,4-Triazol-3-one
Chemical structure:
Chemical structure:
Other posaconazole intermediates:
3. CAS# 170985-85-0 :((2S,3S)-2-(benzyloxy)pentan-3-yl)hydrazinecarboxaldehyde
Chemical structure:
3. CAS# 170985-85-0 :((2S,3S)-2-(benzyloxy)pentan-3-yl)hydrazinecarboxaldehyde
Chemical structure:
4. CAS# 184177-81-9 : phenyl N-[4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl]carbamate
Chemical structure:
Chemical structure:
5. CAS# 183871-36-5 : ((2S,3S)-2-(benzyloxy)pentan-3-yl)hydrazine dibenzoyl-D-tartrate
Chemical structure:
Chemical structure:
7. CAS#149809-43-8: (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethyl ester
1. Brightgene Biomedical
2. Langfang Gaobo
3. Pingdingshan Chemiway
4. Zhangjiakou Gerui
......
* For detailed information or contact information of posaconazole manufacturers, please leave message or send email to: michaelapci@gmail.com
ROS: Synthesis of Posaconazole for reference:
Title: | Tetrahydrofuran antifungals |
Authors: | Saksena, A.K.; Girijavallabhan, V.M.; Lovey, R.G.; Pike, R.E.; Wang, H.; Liu, Y.-T.; Ganguly, A.K.; Bennett, F. (Schering Corp.) |
Source: | EP 0736030; JP 1997500658; US 5661151; US 5703079; WO 9517407 |
Itraconazole (1992, Janssen)

fluconazole (1988, Pfizer)

Voriconazole (2002, Pfizer)

Isavuconazole (2015, Basilea, Astellas ),

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