Reliable manufacturers of Alectinib and its intermediates

Alectinib

Alectinib is one of the "tinib" Tyrosine-kinase inhibitors. It is an oral drug that blocks the activity of anaplastic lymphoma kinase (ALK) and is used to treat non-small-cell lung cancer (NSCLC). It was developed by Chugai Pharmaceutical Co. Japan.

Generic name: n/a
Brand name: Alecensa
Therap-Cat: anti-cancer

Indications, Side Effects, Warnings Consumer Information of Alectinib please refer to: www.drugs.com

Chemical information of Alectinib:

Chemical name：

• 9-Ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

CAS#: 1256580-46-7

Chemical structure:

List of manufacturers approved for Generic Alectinib:

n/a

List of manufacturers applied DMF for Alectinib: (by June 2017, data from www.fda.gov):

n/a

Manufacturers of Alectinib in China (data from www.sfda.gov.cn):

n/a

Intermediates of Alectinib:

1. CAS# 1256578-99-0 : 6-bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one

2. CAS# 4133-34-0: 3,4-Dihydro-7-methoxy-2(1H)-naphthalenone

3. CAS# 1256579-06-2: 9-Bromo-8-hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

4. CAS# 120983-72-4: 1-chloro-1-chloroacetylcyclopropane;

5. CAS# 17672-26-3: 3-hydrazinylbenzonitrile

Manufacturers of Alectinib intermediates:

1. Zhejiang Ausun

2. Tianjin Reliable Pharmatech

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