Reliable manufacturers of Sacubitril and its intermediates

Sacubitril

Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug valsartan/sacubitril (during trials as LCZ696), is a treatment for heart failure.
Sacubitril is a prodrug that is activated to sacubitrilat (LBQ657) by de-ethylation via esterases.

Generic name: Sacubitril
Brand name: Entresto
Therap-Cat: cardiovascular

Indications, Side Effects, Warnings Consumer Information of Entresto please refer to: www.drugs.com

Chemical information of Sacubitril:

Chemical name: 

• 4-{[(2S,4R)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid
• CAS#: 149709-62-6

Chemical structure:

List of manufacturers approved for Generic Sacubitril:

n/a

List of manufacturers applied DMF for Sacubitril: (by June 2017, data from www.fda.gov):

1. MYLAN LABORATORIES LTD

List of manufacturers of Sacubitril in China (data from www.sfda.gov.cn):

n/a

Intermediates of Sacubitril:

1. CAS#1012341-50-2 : (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid

Chemical structure:

2.CAS#1012341-48-8: (2E,4R)-5-[1,1'-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic acid
Chemical structure:

Manufacturers of Sacubitril intermediates:

1. Jiangsu Vcare

2. Tianjin Reliable Pharmatech

3. Cangzhou Enke

......

* For detailed information or contact information of posaconazole manufacturers, please leave message or send email to: michaelapci@gmail.com

Reliable manufacturers of Alectinib and its intermediates

Alectinib

Alectinib is one of the "tinib" Tyrosine-kinase inhibitors. It is an oral drug that blocks the activity of anaplastic lymphoma kinase (ALK) and is used to treat non-small-cell lung cancer (NSCLC). It was developed by Chugai Pharmaceutical Co. Japan.

Generic name: n/a
Brand name: Alecensa
Therap-Cat: anti-cancer

Indications, Side Effects, Warnings Consumer Information of Alectinib please refer to: www.drugs.com

Chemical information of Alectinib:

Chemical name：

• 9-Ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

CAS#: 1256580-46-7

Chemical structure:

List of manufacturers approved for Generic Alectinib:

n/a

List of manufacturers applied DMF for Alectinib: (by June 2017, data from www.fda.gov):

n/a

Manufacturers of Alectinib in China (data from www.sfda.gov.cn):

n/a

Intermediates of Alectinib:

1. CAS# 1256578-99-0 : 6-bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one

2. CAS# 4133-34-0: 3,4-Dihydro-7-methoxy-2(1H)-naphthalenone

3. CAS# 1256579-06-2: 9-Bromo-8-hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

4. CAS# 120983-72-4: 1-chloro-1-chloroacetylcyclopropane;

5. CAS# 17672-26-3: 3-hydrazinylbenzonitrile

Manufacturers of Alectinib intermediates:

1. Zhejiang Ausun

2. Tianjin Reliable Pharmatech

......

* For detailed information or contact information of posaconazole manufacturers, please leave message or send email to: michaelapci@gmail.com

Reliable manufacturers of Ezetimibe and its intermediates

Ezetimibe

Ezetimibe is recommended as second line therapy for those intolerant of statins or unable to achieve target LDL cholesterol levels on statins alone by several major medical group practice guidelines.
Marketed by MSD.

Generic name: EZETIMIBE
Brand name： Zetia, Ezetrol
Therap-Cat: Cardiovascular(lowers plasma cholesterol levels)

Indications, Side Effects, Warnings Consumer Information of Ezetimibe please refer to: www.drugs.com

Chemical information of Ezetimibe:

Chemical name：(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one

CAS#: 163222-33-1

Chemical structure:

List of manufacturers approved for Generic Ezetimibe:

1. MYLAN (EZETIMIBE; EZETIMIBE SIMVASTATIN)
2. GLENMARK
3. DR REDDYS (EZETIMIBE AND SIMVASTATIN)
4. IMPAX (EZETIMIBE AND SIMVASTATIN)
5. WATSON (Actavis, Allergan, Generics division sold to Teva in 2016) (EZETIMIBE; EZETIMIBE AND ATORVASTATIN CALCIUM; EZETIMIBE AND SIMVASTATIN)
6. TEVA
7. SANDOZ
8. ZYDUS
9. OHM LABS
10. APOTEX
11. AMNEAL PHARMS

List of manufacturers applied DMF for Ezetimibe: (by June 2017, data from www.fda.gov):

1. GLENMARK
2. TEVA
3. MSN
4. NEULAND
5. LUPIN
6. CHANGZHOU PHARMACEUTICAL
7. MYLAN
8. SIGNA
9. DR. REDDYS
10. WATERSTONE
11. HETERO
12. WUHAN ZY PHARMACEUTICAL
13. AUROBINDO
14. MACLEODS
15. RAKS PHARMA

Manufacturers of Ezetimibe in China (data from www.sfda.gov.cn):

1. BEIJING TIANHENG
2. SHANDONG BOYUAN
3. HUNAN NANXIN
4. HUIZHOU SALUBRIS
5. YANTAI VALIANT
6. SICHUAN PHARMACEUTICAL
7. WUXI FORTUNE
8. SHANDONG LANGNUO
9. JIANGXI SHIMEI
10. CHENGDU HENGRUI
11. HUBEI WATERSTONE
12. JIANGSU DEYUAN
13. HUBEI JINGJIANG RIVER SOURCE
14. HANSYN PHARMA
15. SHANDONG KONGFU

...... 

Intermediates of Linezolid:

1. CAS#204589-80-0: (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4- (phenylmethoxy)phenyl]- 3-azetidinepropanoic acid, methyl ester

Chemical Structure: 

2. CAS#163222-32-0: 1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-(phenylmethoxy)phenyl]-,(3R,4S)-2-Azetidinone

Chemical Structure: 

3. CAS#70627-52-0: N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Chemical Structure:

4. CAS#190595-65-4: 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(phenylmethoxy)phenyl]-,(3R,4S)-2-Azetidinone

Chemical Structure:

5. CAS#272778-12-8: 3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-[(4-fluorophenyl( amino)]] [4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)- 2-oxazolidinone

Chemical Structure:

6. CAS#189028-93-1: 3-[5-(4-fluorophenyl)-1,5-dioxopentyl]-4-phenyl-(4S)-2-oxazolidinone

Chemical Structure:

Manufacturers of Ezetimibe intermediates:

1. Shanghai Desano

2. Zhangjiakou Gerui

3. Zhejiang Tianyu

4. Menovo

......

* For detailed information or contact information of posaconazole manufacturers, please leave message or send email to: michaelapci@gmail.com

*ROS: Synthesis of Ezetimibe for reference :

Title	Hydroxy-substd. azetidinone cpds. useful as hypocholesterolemic agents
Authors	Rosenblum, S.B.; Dugar, S.; Burnett, D.A.; Clader, J.W.; McKittrick, B.A. (Schering Corp.)
Source	EP 0720599; JP 1996509989; US 5631365; WO 9508532

Reliable manufacturers of Linezolid and its intermediates

Linezolid

Linezolid is an oxazolidinone, protein synthesis inhibitor: stop the growth and reproduction of bacteria by disrupting translation of messenger RNA (mRNA) into proteins in the ribosome.

Generic name: LINEZOLID
Brand name： ZYVOX
Therap-Cat: Antibiotic

Indications, Side Effects, Warnings Consumer Information of linezolid please refer to: www.drugs.com

Chemical information of Linezolid:

Chemical name：(s)-n-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide

CAS#: 165800-03-3

Chemical structure:

List of manufacturers approved for Generic Linezolid:
1. TEVA
2. WEST-WARD PHARMS
3. HOSPIRA
4. SANDOZ
5. MYLAN
6. GLENMARK
7. HETERO
8. AMNEAL
9. ALEMBIC
10. GATE PHARMS
11.FRESENIUS KABI
12. AUROBINDO
13. NOVEL LABS
14. NANG KUANG PHARM
15. ZYDUS PHARMS
16. SAGENT PHARMS
17. HQ SPCLT PHARMA

List of manufacturers applied DMF for Linezolid:
1. TEVA
2. GLENMARK
3. SYMED LABS
4. NEULAND

5. ALEMBIC
6. APOTEX
7. DR REDDYS

8. FORMOSA

9. RAKS PHARMA
10. UNION QUIMICO
11. USV PRIVATE
12. ZHEJIANG NEO DANKONG
13. JUBILANT
14. CADILA HEALTHCARE
15. AMOLI ORGANICS
16. LACAMAS
17. ZHEJIANG HISUN
18. MACLEODS

Manufacturers of Linezolid in China (data from www.sfda.gov.cn):

1. Shanghai Desano
2. CNPICL
3. Xiamen Encheng
4. Beijing Cell Technology
5. VenturePharma
6. Haimen Wisdom
7. Shanghai Shyndec Haimen
8. Henan Tailong
9. Hansoh Pharma (Lianyungang Hongchuang)
10. Beijing Winsunny Harmony(NHU Group)
11. Hubei Guangji
12. Zhejiang Huahai
13. Shandong Xinyi
14. Weihai Disu
15. Huazhong Pharma
......

Intermediates of Linezolid:

1. CAS# 168828-82-8 : (5R)-(hydroxymethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]oxazolidin-2-one
   chemical structure: 
2. CAS# 174649-09-3:
   (R) - (3 - (3- fluoro-4- morpholinophenyl) - 2- oxo-5-oxazolidinyl) methyl methanesulfonate
   
   
   

Reliable manufacturers of Linezolid intermediates:
1. Zhangjiakou Gerui
2. Zhejaing Neo-Dankong
3. Creative Organics
4. Perato Chem
5. Air Sea (Taizhou) 
......

* For detailed information or contact information of Linezolid manufacturers please leave message or send email to: michaelapci@gmail.com

ROS: Synthesis of Linezolid for reference:

Title:	Substd. oxazine and thiazine oxazolidinone antimicrobials
Authors:	Barbachyn, M.R.; Brickner, S.J.; Hutchinson, D.K. (Pharmacia Corp.)
Source:	EP 0717738; JP 1997502436; WO 9507271

Reliable manufacturers of posaconazole and its intermediates

Posaconazole

Posaconazole is a triazole antifungal drug, marketed by Schering-Plough. It is a derivative of Itraconazole.
Generic Name: posaconazole
Brand Name: Noxafil, Posanol

Indications, Side Effects, Warnings Consumer Information of posaconazole please refer to: www.drugs.com

Chemical information of posaconazole:

CAS#: 171228-49-2

Chemical name：4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one

Chemical structure:

List of manufacturers approved for Generic posaconazole: none

List of manufacturers applied DMF for posaconazole: (by June 2017, data from www.fda.gov):
1. SANDOZ PRIVATE LTD (2010)
2. MSN LABORATORIES PRIVATE LTD (2013)
3. WUHAN ZY PHARMACEUTICAL CO LTD (2014)
4. BRIGHTGENE BIOMEDICAL TECHNOLOGY CO LTD (2014)
5. MSN LABORATORIES PRIVATE LTD (2015)
6. ZHEJIANG AUSUN PHARMACEUTICAL CO LTD(2016)
7. APOTEX PHARMACHEM INC (2016)
8. STRIDES SHASUN LTD (2017)

List of manufacturers of posaconazole in China (data from www.sfda.gov.cn):
1. Nanjing Zhengke
2. Jiangsu Hengsheng
3. Jiangsu Aosaikang
4. Chongqing Huabang Shengkai
5. Xinxiang Shuanglu
6. Henan Tailong
7. Shanghai Xiandai
8. Hebei Guolong
9. Jichuan Pharma
10. Wuhan Zhongyou
11. Shanxi Zhendong
12. Jiangsu Shengdi
13. Jiangsu Haici Bio-pharm
14. Chengdu Beite
15. Shanxi Pude

Intermediates of posaconazole:

Advanced posaconazole intermediates:
1. CAS# 175712-02-4 ：(5R-cis)- p-Chlorobenzenesulfonic acid 5-(2,4-difluoro-
phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethyl ester
Chemical structure:

2. CAS# 184177-83-1 : 2-[(1S,2S)-1-ethyl-2-bezyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- 3H-1,2,4-Triazol-3-one
Chemical structure: 

Other posaconazole intermediates:
3. CAS# 170985-85-0 :((2S,3S)-2-(benzyloxy)pentan-3-yl)hydrazinecarboxaldehyde
Chemical structure:

4. CAS# 184177-81-9 : phenyl N-[4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl]carbamate
Chemical structure:

5. CAS# 183871-36-5 : ((2S,3S)-2-(benzyloxy)pentan-3-yl)hydrazine dibenzoyl-D-tartrate
Chemical structure:

6. CAS# 74853-08-0 : 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine
Chemical structure:

7. CAS#149809-43-8: (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethyl ester

Chemical structure: 

Manufacturers of posaconazole intermediates:

1. Brightgene Biomedical
2. Langfang Gaobo
3. Pingdingshan Chemiway
4. Zhangjiakou Gerui
......

* For detailed information or contact information of posaconazole manufacturers, please leave message or send email to: michaelapci@gmail.com

ROS: Synthesis of Posaconazole for reference:

Title:	Tetrahydrofuran antifungals
Authors:	Saksena, A.K.; Girijavallabhan, V.M.; Lovey, R.G.; Pike, R.E.; Wang, H.; Liu, Y.-T.; Ganguly, A.K.; Bennett, F. (Schering Corp.)
Source:	EP 0736030; JP 1997500658; US 5661151; US 5703079; WO 9517407

Drugs similar with posaconazole: 
Itraconazole (1992, Janssen)



fluconazole (1988, Pfizer)

Voriconazole (2002, Pfizer)

Isavuconazole (2015, Basilea, Astellas ),