Reliable manufacturers of Sacubitril and its intermediates

Sacubitril

Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug valsartan/sacubitril (during trials as LCZ696), is a treatment for heart failure.
Sacubitril is a prodrug that is activated to sacubitrilat (LBQ657) by de-ethylation via esterases.

Generic name: Sacubitril
Brand name: Entresto
Therap-Cat: cardiovascular

Indications, Side Effects, Warnings Consumer Information of Entresto please refer to: www.drugs.com

Chemical information of Sacubitril:

Chemical name: 

• 4-{[(2S,4R)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid
• CAS#: 149709-62-6

Chemical structure:

List of manufacturers approved for Generic Sacubitril:

n/a

List of manufacturers applied DMF for Sacubitril: (by June 2017, data from www.fda.gov):

1. MYLAN LABORATORIES LTD

List of manufacturers of Sacubitril in China (data from www.sfda.gov.cn):

n/a

Intermediates of Sacubitril:

1. CAS#1012341-50-2 : (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid

Chemical structure:

2.CAS#1012341-48-8: (2E,4R)-5-[1,1'-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic acid
Chemical structure:

Manufacturers of Sacubitril intermediates:

1. Jiangsu Vcare

2. Tianjin Reliable Pharmatech

3. Cangzhou Enke

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